Comparison of Premixed Insulins Aspart 30, Aspart 70 and Aspart on Postprandial Lipids

Medical University of Graz20 enrolled

Overview

The aim of the study is to investigate meal-related treatment with either premixed Insulin Aspart 30, Aspart 70 and Aspart with regard to postprandial glucose, triglyceride and free fatty acids excursions after a standard breakfast and lunch.

Whereas the effects of each of the established types of insulin (remixed Insulin Aspart 30, Aspart 70 and Aspart) have been shown before, their specific glucose and lipid lowering capacities have so far not been investigated in a simulated physiological situation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes

Interventions

Insulin AspartDRUG

Patients received insulin aspart before breakfast and before lunch.

Insulin Aspart 30DRUG

Patients received biphasic insulin aspart 30 before breakfast and before lunch.

Insulin Aspart 70DRUG

Patients received biphasic insulin aspart 70 before breakfast and before lunch.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Type-II Diabetes * BMI \> 27 kg/m2 * age 35 to 75 years * HbA1c \< 8.5% * informed consent * treatment with pre-mixed insulin * stabile dose of insulin for at least 4 weeks Exclusion Criteria: * Type-I Diabetes mellitus * HbA1c \> 8.5 % * Serum Creatinine \> 1.7 mg/dl * Alaninaminotranferase or Aspartataminotransferase \> 3x Upper Limit of Normal * treatment with sulfonylurea or gliptins * treatment with glitazones * manifest clinical infections * treatment with glucocorticoids or antipsychotic drugs * psychiatric diseases * alcohol abuse * myocardial infarction or stroke within the previous 3 months * surgery within the previous 3 months

Locations (1)

Medical University of Graz, Department for Internal Medicine

Graz, Austria

Outcomes

Primary Outcomes

Area Over Basal for Postprandial Glucose From 0 to 600min

Area over basal for postprandial glucose from 0 (Fasting glucose, measured at daily study start) to 600 min (after breakfast) Area over basal is calculated according to the trapezoidal rule.