Assessment of Protective Effect of JOINS on Cartilage in Knee Osteoarthritis

Inclusion Criteria: 1. A female is eligible if she is of: * Non-child bearing potential (i.e., physiologically incapable of becoming pregnant), including any female who is at least 2 year after post- menopausal * Child bearing potential and agrees to the acceptable contraceptive methods used consistently and correctly * Pregnancy test result of negative at screening 2. Primary Knee OA(Osteoarthritis) on medial femorotibial compartment based on ACR(American College Rheumatology) Criteria. * ACR Criteria : With Knee pain and satisfied at least 1 of 3 (① age \> 50 years, morning stiffness \< 30 minute, ③ Presence of Crepitus and Osteophytes on motion) 3. Appropriately signed and dated informed consent has been obtained Exclusion Criteria: 1. Rheumatoid arthritis or inflammatory arthritis. 2. Bilateral total knee replacement already treated, or planning for the procedure. 3. Knee prosthesis already implanted, or foreseen within the next year. 4. Clinically significant hip osteoarthritis. 5. Severe renal insufficiency defined as creatinine clearance \< 30ml/mln(Cockcroft formula). 6. Clinically significant pulmonary, hepatic, renal or heart disorder or diagnosis crucial disease by investigator ( Glycosuria(Diabetes mellitus) or asthma patients are excluded from this clinical study and the patients who has a clinically significant disease are also excluded.). 7. MRI contraindications : overweight, inferior limb diameter non-fitting the knee antenna, inserted pace-maker, metallic prosthesis( if known to interfere with MRI procedure or if known to be unsafe for MRI), metallic clips, insulin pump, cytostatic pump, hearing aid, essential tremor, claustrophobia, etc,. 8. Allergic reaction to Clinical trial medication. 9. Other clinical trial drugs during the 1 month prior to the screening visit.