FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers

Inclusion Criteria: * AST, ALT, alkaline phosphatase and bilirubin \< or =1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%). * Healthy as determined by a responsible and experienced physician * Male or female between 18 (20 for Japanese) and 65 years of age inclusive * Male subjects with female partners of child-bearing potential must agree to use one of the contraception methods * Body weight \> or = 50 kg and BMI within the range 18.5 - 29.9 kg/m2 (inclusive). * Capable of giving written informed consent * Average QTc, QTcB or QTcF \< 430 msec. * For Japanese subjects Japanese ancestry defined as being born in Japan, having four ethnic Japanese grandparents, holding a Japanese passport or identity papers and being able to speak Japanese. Exclusion Criteria: * Hepatitis B or Hepatitis C positive * Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). * A positive pre-study drug/alcohol screen. * HIV positive * History of regular alcohol consumption within 6 months of the study * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) prior to the first dose of study medication * History of sensitivity to any of the study medications, or components thereof * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Pregnant females * Unwillingness or inability to follow the procedures outlined in the protocol. * Subject is mentally or legally incapacitated. * Regular use of tobacco- or nicotine-containing products within 6 months prior to screening. * Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the first dose of study medication. * Subjects will be screened such that those subjects exhibiting rapid gastric emptying rates (t½b \< 75 min) will be excluded