Crossover clinical evaluation three contact lens care regimens used for one month with Acuvue Oasys lenses.
This is a three-arm crossover clinical evaluation of 40 subjects who will use each of three contact lens care regimens for one month with Acuvue Oasys lenses. The subjects will be randomized on the order of solutions used: Investigational MPS, ClearCare, and Opti-Free RepleniSH MPS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
40
For the cleaning, rinsing, and storage of soft contact lenses.
Peroxide-based regimen for cleaning and disinfecting soft contact lenses.
Multi-purpose disinfecting solution for the cleaning, rinsing and storing of soft contact lenses.
Centre for Contact Lens Research
Waterloo, Ontario, Canada
Corneal Staining
Corneal staining will be assessed with sodium fluorescein dye on the ocular surface. The cornea is split into 5 sections, each section is evaluated by staining type, depth, and extent is graded on a 0 to 100 scale with higher scores indicating more staining. The possible total range for the total score per eye is 0 to 50,000 (100x100x100=10,000 per section) with values higher than 1200 being clinically relevant.
Time frame: 4 weeks
Subjective Lens Wearing Comfort
This will be assessed by a questionnaire on patient-perceived lens comfort and any symptoms of discomfort on a 0 to 100 scale.
Time frame: 4 weeks
Dryness
This will be assessed by the tear break-up time on the lens surface, measured in seconds.
Time frame: 4 weeks
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