Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy

Assistance Publique Hopitaux De Marseille25 enrolled

Overview

Diagnosis of diabetic cardiomyopathy is then retained, supposing a change in the coronary microcirculation linked to an endothelial dysfunction. Abnormalities of the myocardial metabolism is frequently associated. It is regrettably about a hypothesis difficult to verify with current medical techniques.This deficiency being not only harmful to the diagnosis, but also to the assessment of the efficiency of the medical treatment on the myocardial metabolism and the endothelial function. Techniques of nuclear magnetic resonance offer interesting perspectives.

These techniques allow in this context: 1. to quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers. The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique. 2. to estimate the metabolic and structural abnormalities in this population, with particularly: * Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31. * Structural abnormalities: become integrated into the description of diabetic cardiomyopathy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Diabetic Cardiomyopathy

Interventions

NUCLEAR MAGNETIC RESONANCE IMAGINGOTHER

Techniques of nuclear magnetic resonance offer interesting perspectives in this context, and particularly to quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers.

NUCLEAR MAGNETIC RESONANCE IMAGINGOTHER

Techniques of nuclear magnetic resonance offer interesting perspectives in this context, and particularly to quantify the myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique and to estimate the metabolic and structural abnormalities in this population.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * more than 18 years old * patient type 2 diabetes affects taken care more than 5 years to Timone Hospital * patient with a diabetic cardiomyopathy * informed and consented Exclusion Criteria: * less than 18 years * Pregnant woman * patient type 1 diabetes affects * patient presents a cardiomyopathy mixed (no diabetic) * patients presents an arrhythmia ventriculaire or above - ventriculaire * Unstable hémodynamique patients

Outcomes

Primary Outcomes

To quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers

The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique.

Time frame: 12 months

Secondary Outcomes

To estimate the metabolic and structural abnormalities in this population

* Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31 which allows to estimate the energy state of the heart by analyzing the phosphorous metabolites with high energy involved in the myocardial energetic metabolism. * Structural abnormalities: evaluation of the fibrosis and the collagenic deposits by T1 mapping and measurement of relaxation T2 as well as the study of the late enhancement of gadolinium. These structural abnormalities become integrated into the description of diabetic cardiomyopathy.