Surgery Versus Radiosurgery for the Treatment of Single Brain Metastases

Inclusion Criteria: 1. Biopsy proven malignancy (original biopsy is adequate as long as the brain imaging is consistent with brain metastases) 2. Patients \> 18 years 3. A contrast-enhanced MRI demonstrating the presence a single brain metastases \<3cm performed within one month prior to registration 4. Life expectancy \> 3 months 5. RPA Class 1 and RPA Class 2 patients with stable primary disease 6. Patients must have normal organ and marrow function 7. Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately 8. ECOG Performance Status 0-2 9. Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: 1. Have tumor(s) in the midbrain, pons, or medulla, in eloquent cortex 2. Have tumors within 10 millimeters of the optic apparatus (nerves and chiasm) or the area postrema 3. Be poor operative candidates from an anesthetic point of view secondary to other major medical illnesses 4. Have a coagulopathy demonstrated by an abnormal prothrombin time, activated partial thromboplastin time, or thrombocytopenia (platelet count less that 150,000 platelets/mm3) 5. Have radiographic or cerebrospinal fluid specimen evidence of widespread leptomeningeal metastasis 6. Significant psychiatric impairments which, in the opinion of the investigators, will interfere with the proper administration or completion of the protocol 7. Acute or untreated infections (viral, bacterial or fungal) 8. Be prisoners or other institutionalized individuals 9. Have a diagnosis of germ cell tumor, lymphoma or small cell lung cancer 10.Concurrent chemotherapy or molecularly targeted anti-cancer therapy 11.Allergy to Gadolinium 12.Imminent brain herniation, massive peritumoural oedema or hydrocephalus 13.Have any metallic implant that would exclude the possibility of having a brain MRI