The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis

Assuta Hospital Systems30 enrolled

Overview

Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.

The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Rhinosinusitis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with chronic rhinosinusitis who: * Failed conservative medical treatment. * Stopped treatment (topical or systemic corticosteroids) at least two months before endoscopic sinus surgery. * Had a Lund-MacKay CT score of 2 and higher of 24 available. Exclusion Criteria: * Immunosuppressed patients. * Patients in whom a pathologic evaluation of the middle turbinate was necessary (e.g., suspected neoplastic disorder). * Patients with a Lund-MacKay CT score \< 2 of 24 available. * Pregnant women. * Patients who underwent prior endoscopic sinus surgery.

Locations (1)

AssutaHS

Tel Aviv, Israel

RECRUITING

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.