Clinical Study to Evaluate the Maximum Tolerated Dose of BAY87-2243 in Patients With Advanced Malignancies

Inclusion Criteria: * Male or female subjects aged \>/= 18 years * Subjects with advanced, histologically or cytologically confirmed solid tumors, refractory to any standard therapy, have no standard therapy available, or subjects must have actively refused any treatment which would be regarded standard, and / or if in the judgement of the investigator, experimental treatment is clinically and ethically acceptable * Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2 * Life expectancy of at least 3 month * Adequate bone marrow, liver, and renal functions Exclusion Criteria: * History of cardiac disease including congestive heart failure \> NYHA (New York Heart Association) II, unstable angina (anginal symptoms at rest), or new-onset angina (within the past 3 months) or myocardial infarction within the past 6 months and cardiac arrhythmias requiring anti-arrhythmic therapy except for beta-blockers and digoxin * History of ischemic cardiovascular disease * Family history of long QT syndrome * Persistent hypokalemia \< 3.5 mmol/L * History of cerebral ischemia including transient ischemic attack (TIA), prolonged reversible ischemic neurologic deficit (PRIND), and ischemic stroke within the past 6 months * Known alcohol abuse * Moderate or severe hepatic impairment, i.e. Child-Pugh class B or C * Diabetes mellitus treated with oral antidiabetics or insulin * History of human immunodeficiency virus (HIV) infection or chronic hepatitis B or C * Active clinically serious infections of CTCAE \> Grade 2 (Common Terminology Criteria for Adverse Events v4.02) * Symptomatic metastatic brain or meningeal tumors unless the subject is \> 6 months from definitive therapy, has no evidence of tumor growth on an imaging study within 4 weeks prior to study entry, and is clinically stable with respect to the tumor at the time of study entry. * Unresolved specific chronic toxicity CTCAE \> Grade 2 * Subjects may not receive potent inducers of CYP3A4, such as phenytoin, carbamazepine, and rifampicin, as the oral clearance of ondansetron may increase and ondansetron plasma concentrations may decrease due to antiemetic regimen * Concomitant medication with metformin * Concomitant medication with drugs known to prolong the QT interval * Relevant pathological changes in the ECG such as a second or third-degree AV block, prolongation of the QRS complex over 120 ms or of the QT / QTc-interval over 450 ms in men and women