Evaluation of Neuroprotective Effect of Minocycline

Shahid Beheshti University of Medical Sciences

Overview

This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened . Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years . How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher. In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Conditions

Retinal Detachment

Interventions

placeboDRUG

100mg,BD, fo three month

MinocyclineDRUG

100mg

Eligibility

Sex: ALLMin age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age over 8 years old * gender of both sex * normal liver and renal function * informed consent received from all patients * no pregnancy and no lactation * minimal sun exposure Exclusion Criteria: * old RD * diabetic retina * previous retinal surgery CRF\& liver disfunction RD + PVR \> B Hyper sensitivity to tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )

Locations (1)

Labbafinejad medical center

Tehran, Tehran Province, Iran

RECRUITING

Outcomes

Primary Outcomes

BCVA

outcome method of measurement: Snellen chart

Time frame: changes of BCVA in 3 month

Secondary Outcomes

finding of ERG changes

outcome method of measurement: ERG( testes)

Time frame: 3 months

finding of OCT changes

outcome method of measurement: OCT

Time frame: 3 months

finding of FAF changes

outcome method of measurement: FAF( testes)

Time frame: 3 months

Data from ClinicalTrials.gov

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