Colistin Plus Rifampicin in MDR P. Aeruginosa and A. Baumanii

Inclusion Criteria: * Age\>18 years * Hospitalized to Siriraj Hospital * Infection with MDR A.baumanii or P.aeruginosa * Nescessary for treatment with Colistin * Patient agrees to participate by giving written informed consent. Exclusion Criteria: * pregnancy or lactating mother * Colistin or Rifampicin allergy * Active hepatic disease or abnormal liver function test * patient who suspected infection with mycobacterium tuberculosis * patient who can not drug by enteral feeding