In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A. baumannii In this study, we compare the clinical and microbiologicalresponse of colistin alone versus colistin plus fosfomycin in treatment of A. baumannii infected patients
Inclusion criteria * Age\> 18 years * Hospitalized to Siriraj Hospital * Infected caused by A. baumannii * Need Colistin treatment Exclusion criteria * Pregnancy or Lactating mother * Colistin or Fosfomycin Allergy * Patients who have severe abnormal renal or liver function
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
92
Colistimethate sodium 2.5-5mg/kg of colistin base
colitimethate sodium 2.5-5mg/kg iv plus fosfomycin 2gm iv every 12 hours
Siriraj Hospital
Bangkok, Bangkok, Thailand
RECRUITINGnumber of subjects with cure or improvement
cure improvement worse death
Time frame: up to 28days
number of subjects with eradication of causative bacteria
eradication persistence superinfection
Time frame: up to 28days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.