Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease. Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).
Study Type
OBSERVATIONAL
Enrollment
47
Methacholine challenge test to evaluate airway hyperreactivity
Fractional Exhaled NO to evaluate eosinophilic inflammation
Blood Tests (Eosinophil Count)
Rambam Medical Center
Haifa, Israel
Methacholine challenge test
As assessed by methacholine challenge test with determination of PC20.
Time frame: 18 months
Fractional Exhaled NO
Exhaled NO test
Time frame: Day 1
Eosinophils count
blood test
Time frame: Day 1
Pediatric Crohn's Disease Activity Index (PCDAI)
Clinical Evaluation
Time frame: Day 1
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Clinical Evaluation for Pediatric Crohn's Disease Activity Index (PCDAI)