In 2005, Wyeth conducted study 0887X-101518 (NCT00488826) in which Chinese infants received either Prevenar alone (Group 1), Prevenar given with a Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccine (Group 2) or DTaP alone (Group 3). This follow up study (at least 3 years after the last vaccination) will assess the antibody concentrations in children who previously completed Wyeth study 0887X-101518.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
335
One 5mL blood draw for immunogenicity at least 3 years post completion of clinical study 0887X-101518.
Chengxiang Town Hospital
Longan County, Guangxi, China
Longan County CDC
Longan County, Guangxi, China
Nanyu Town Hospital
Longan County, Guangxi, China
Yanjiang Town Hospital
Longan County, Guangxi, China
Geometric Mean Concentration (GMC) for Serotype-specific Pneumococcal Immunoglobulin G (IgG) Antibody, 36 Months After the Toddler Dose
Antibody geometric mean concentration (GMC) as measured by mcg/mL for 7 pneumococcal serotypes (serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F). GMC (7vPnC, 7vPnC/DTaP, and DTap) and corresponding 2-sided 95% confidence intervals (CI) were evaluated. Geometric means (GMs) were calculated using all participants with available data for the specified blood draw.
Time frame: Day 1 (36 months after toddler dose)
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Natong Town Hospital
Longan County, Guangxi, China
Qiaojian Town Hospital
Longan County, Guangxi, China
Gutan Village Hospital
Longan County, Guangxi, China
Dingdang Town Hospital
Longan County, Guangxi, China
Yangwan Hospital
Longan County, Guangxi, China
GuangXi Center for Disease Prevention and Control
Nanning, Guangxi, China