Growth Hormone (GH) in in Vitro Fertilization (IVF) Poor-responder Patients

Inclusion Criteria: * Women who desire pregnancy with regular spontaneous menstrual cycles of 25-30 days length. * Infertility requiring IVF with or without ICSI. * Antecedent of a failed previous IVF cycle with a GnRH long agonist protocol in which at least 3000 IU of FSH were used (cancellation due to poor ovarian response - \< 4 mature follicles - or less than 5 oocytes retrieved)and antral follicle count \< 5. * Partner sperm. * Presence of both ovaries and normal uterine cavity. * PAP smear within normality in previous 3 years. * Negative pregnancy test (serum or urine) before rFSH administration. * Willingness of adhesion to protocol during the whole study period. * Signed informed consent given. Exclusion Criteria: * HIV, HCV, HBV positive serologies in women or partner. * Important systemic diseases that could interfere with gonadotrophin treatment (ovarian and hypothalamic tumors...). * BMI \> 32 kg/m2 or antecedent of diabetes mellitus. * Gonadotrophin treatment within the previous 30 days. * Availability of frozen embryos of previous IVF cycles . * Abnormal uterine bleeding. * Previous treatment with LH or LH effect drugs. * Polycystic ovaries, increased size ovaries or presence of ovarian cysts of unknown ethiology. * Contraindication for pregnancy. * Allergies to gonadotrophins or somatotropin. * History of drug or alcohol abuse in the previous 5 years. * Previous enrollment in this study or simultaneous participation in another study with drugs.