This study is to look at a new vaccine that might prevent meningococcal disease, and to look at the safety of the new vaccine as well as how well it is tolerated. This study will also look at this vaccine being given 2 or 3 times. This study will be done in healthy adolescents.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
1,714
Percentage of Participants Achieving Serum Bactericidal Assay Using Human Complement (hSBA) Titer Greater Than or Equal to (>=) Lower Limit of Quantitation: Group 1 and 2 Participants
Time frame: 1 month after Injection 4
Percentage of Participants Reporting At Least 1 Adverse Event (AE)
Time frame: Injection 1 up to 1 month after Injection 4
Percentage of Participants Achieving hSBA Titer >=LLOQ: Group 3 Participants
Time frame: 1 month after Injection 4
Serum Bactericidal Assay Using Human Complement (hSBA) Geometric Mean Titers (GMTs)
Time frame: Before Injection (Inj) 1, 1 Month (M) after (aft) Injection 2, 3, 4
Percentage of Participants Achieving hSBA Titer >=LLOQ
Time frame: Before Injection 1, 1 Month after Injection 2, 3, 4
Percentage of Participants With Serum Bactericidal Assay Using Human Complement (hSBA) Titer >= Prespecified Titer Level
Time frame: Before Injection 1, 1 Month after Injection 2, 3, 4
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rLP2086 at visits 1 and 3, saline at visits 2 and 5
rLP2086 at visits 3 and 5, saline at visits 1 and 2
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...and 53 more locations