Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative Thrombotic Thrombocytopenic Purpura (TTP)

Johann Wolfgang Goethe University Hospital70 enrolled

Overview

The purpose of this study is to determine whether extracorporeal circulation during cardiac surgery has an influence on ADAMTS13-Activity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * cardiac surgery with or without (OPCAB) the use of extracorporeal circulation * patient agrees Exclusion Criteria: * no agreement * known TTP in medical history

Locations (1)

Johann Wolfgang Goethe University Hospital

Frankfurt am Main, Hesse, Germany

RECRUITING

Outcomes

Primary Outcomes

Change in ADAMTS13-Activity over time

Time frame: during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery

Secondary Outcomes

Change in ADAMTS13-Antibody over time

Time frame: during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery

Change in Platelet count over time

Time frame: during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery

time duration of extracorporeal circulation during surgery

Time frame: during surgery

Amount of intraoperative given fluid replacement

Time frame: during surgery

Amount of given blood products (red blood cells)

Time frame: 24 hours

Central Contacts

Wolfgang Miesbach

CONTACT

+49696301 wolfgang.miesbach@kgu.de

Imke R Reinecke

CONTACT

ireineck@stud.uni-frankfurt.de

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.