Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy

Massachusetts General Hospital8 enrolled

Overview

This is a developmental protocol to determine the MRI based 31P-MRS changes seen in subjects with mitochondrial myopathy using our dynamic exercise protocol and to identify the ideal variable(s) to represent mitochondrial function.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mitochondrial Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Men and women ≥ age 18 years old with primary mitochondrial myopathy 2. Known alteration in electron transport chain activity (\<25 % activity of ETC) or known mutations in mitochondrial gene. Exclusion Criteria: Failure based on standard clinical MRI Screening form - the form is intended to establish the safety of subjects participating in the MRI scan without divulging any confidentiality information -

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

PCr recovery after submaximal exercise by 31P-MRS

Time frame: 1 year

Data from ClinicalTrials.gov

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