This study is designed to investigate the comparison between alpha blocker monotherapy and 5-alpha-reductase inhibitor monotherapy following combination therapy in benign prostatic hyperplasia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
308
alpha blocker and 5-alpha-reductase inhibitor medication
alpha blocker monotherapy group
5 alpha reductase inhibitor monotherapy
Samsung Medical Center
Seoul, South Korea
Numeric change of IPS and Numeric change of IPSS total score
Time frame: from baseline to 12 months of treatment
Changes in patients' symptom questionnaires : IPSS, ICIQ male LUTS
Time frame: from baseline to 12 months of treatment
Changes in urodynamic parameters : maximal flow rate and PVR
Time frame: from baseline to 12 months of treatment
change in finding of TRUS
Time frame: from baseline to 12 months of treatment
Numeric Change and percent change in PSA
Time frame: from baseline to 12 months of treatment
safety evaluation : incidence and severity of adverse events
Time frame: 12 months of treatment
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