Elderly Patients With Acute Myeloid Leukemia (AML), Maintenance Phase After Complete Remission (CR)

Inclusion Criteria: * Cytologically or histologically confirmed acute myeloid leukemia (AML) with : * At least 60 years of age and fit for intensive chemotherapy: PS \<2 (ECOG) * Absence of significant co-morbidities * Less than 75 years\* of age * LAM with high risk features (blasts \> 20% in bone marrow) * Poor risk cytogenetics * Life expectancy \> 1 month * Affiliated to social security regimen * No granulocytic sarcoma as sole site of disease * Able and willing to provide written and signed informed consent Exclusion Criteria: * Total bilirubin \> 2 times upper limit of normal * AST and ALT and/or alkaline phosphatase \> 4 times upper limit of normal if not in relation with AML. * Factor V \< 50% without DIC (Disseminated Intravascular Coagulation) * NYHA class III or IV congestive heart failure (Echo \< 40%, LVEF \< 50%),Unstable angina pectoris, Serious cardiac arrhythmia * Renal failure not related to AML: serum creatinin \> 170 μmol/L or clearance of creatinin ≤ 50 mL/mn * Known HIV 1- HIV 2 positivity * Prior therapy with azacitidine or lenalidomide * Psychiatric illness or social situations that would preclude compliance with study requirements * Uncontrolled infection * Urgent chemotherapy for DIC, spontaneous tumoral lyse syndrome, leucostase without cytogentic results * Women who are pregnant or breastfeeding * Women who are unwilling or unable to use an acceptable contraceptive method to avoid pregnancy * Men who are unwilling or unable to use an acceptable method of birth control