The Effects of Normobaric Hypoxia on Blood Glucose Levels.

Mike O'Callaghan Military Hospital

Overview

The purpose of this research study is to observe whether there is a change in blood glucose levels in response to a 2 hour oral glucose tolerance tests (OGTT) during acute normobaric hypoxia (short term low oxygen levels at normal ambient air pressure).

Study Type

OBSERVATIONAL

Conditions

Glucose

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (non-diabetics): * Tricare Insurance Beneficiary (military insurance) receiving care at Nellis AFB * 5 males with a BMI \< 25; 5 males with a BMI \> 25 at least 18 years of age (MOFH personnel and DoD beneficiaries). * 5 females with a BMI \< 25; 5 females with a BMI \> 25 at least 18 years of age (MOFH personnel and DoD beneficiaries). Exclusion Criteria (non-diabetics): * History of abnormal fasting glucose. * Pulmonary disease. * Any medications that change glucose control to include systemic steroid and diabetic medications. * History of claustrophobia. * Pregnant or breast feeding. * Non-English speaking. * Physical inability to wear/use the ROBD2 Inclusion Criteria (diabetics): -5 males and/or females, at least 18 years of age, that are type 2 diabetics (MOFH personnel and DoD beneficiaries). Exclusion Criteria (diabetics): * Pulmonary disease. * History of claustrophobia. * Pregnant or breast feeding. * Non-English speaking. * Physical inability to wear/use the ROBD2

Outcomes

Primary Outcomes

Change in glucose levels at altitude

Subjects will be placed on a Reduced Oxygen Breathing Device (ROBD2) to simulate 3 different altitudes at three separate and distinct time periods (ground, 8,000 feet and 12,000 feet) then obtain c-peptide and 2-hour OGTT to determine blood glucose changes during acute normobaric hypoxia.

Time frame: 1 year

Data from ClinicalTrials.gov

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