Anidulafungin vs Amphotericin B Safety in High Risk Hepatic Transplant Recipients

Inclusion Criteria: * At least 18 years old * Signature of ICF * Negative pregnancy test (women of child bearing potential) * Patients who comply with at least one of the following (A or B): A: One of the following criteria (major criteria): * Re-transplant due to severe dysfunction of a previous hepatic graft * Requirement of any renal substitutive therapy, including dialysis or hemofiltration * Fulminant hepatitis requiring hepatic transplant B: Two of the following criteria (minor criteria): * Post-transplant renal impairment (defined as CrCl\< 50 mL/min) 30 days after transplantation * Intra surgery blood transfusion of at least 40 units * Choledochal jejunectomy * 2 or more Candida sp cultures (nasal, pharynx, rectal) from 48 hours pre- to 48 hours post-hepatic transplant * Post transplant re-intervention (laparotomy) Exclusion Criteria: * Hypersensibility to amphotericin B or candin * Patients who have received any other antifungal (excluding fluconazole or oral nystatin for a maximum of 7 days) * Documented or suspected fungal infection * Pregnant women of women who do not accept to us a valid anticonceptive method * Any other disease or medical condition that makes the patient not adequate to participate in the trial