Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood Flow Fluctuations in Glaucoma Patients

Lithuanian University of Health Sciences35 enrolled

Overview

To evaluate whether add-on to prostaglandin therapy with twice a day (bid) dorzolamide is statistically superior to twice a day (bid) timolol with regard to increasing ocular blood flow

Hypotensive treatments for glaucomatous optic neuropathy (GON), depending on their chemical composition can influence the ocular circulation independent of intraocular pressure (IOP) reduction. It is therefore important not only to identify ocular blood flow deficits in GON, but also document the influence of GON treatments on the ocular circulation

Study Type

OBSERVATIONAL

Enrollment

Conditions

Open Angle Glaucoma

Interventions

Color Doppler ImagingDEVICE

Color Doppler imaging (CDI) system for measurements of blood flow in the ophthalmic (OA), central retinal (CRA), and nasal (NPCA) and temporal (TPCA) posterior ciliary arteries. In each vessel, peak systolic velocity (PSV) and end diastolic velocity (EDV) were determined, and Pourcelot's resistive index will be calculated (RI = (PSV-EDV)/PSV).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Open angle glaucoma subjects receiving prostaglandin monotherapy in both eyes Exclusion Criteria: * younger than 18 years old * women of child bearing potential

Locations (1)

Eye Clinic Lithuania Health Science Hospital Kaunas Clinics

Kaunas, Lithuania

Outcomes

Primary Outcomes

Ocular Color Doppler Imaging

Color Doppler Imaging * Nasal post ciliary artery (NPCA) * Temporal posterior ciliary artery (TPCA) * Ophthalmic artery (OA) * Central retinal artery (CRA)

Time frame: 8 AM; 8 PM

Secondary Outcomes

IOP, BP, OPP (mean, fluctuations, amplitude)

IOP, BP, OPP (mean, fluctuations, amplitude) Goldmann applanation tonometry Brachial artery pressure and radial pulse

Time frame: 8 AM-12AM-4PM-8PM

Data from ClinicalTrials.gov

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