Ultrasonography in Juvenile Idiopathic Arthritis

University of Aarhus95 enrolled

Overview

The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Juvenile Idiopathic Arthritis, Oligoarthritis Polyarticular Juvenile Rheumatoid Arthritis Systemic Juvenile Idiopathic Arthritis

Interventions

UltrasonographyDEVICE

Scanning 5 joints bilaterally with an ultrasound scanner

Eligibility

Sex: ALLMin age: 5 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type. * Informed consent from parents * between 5-15 years of age Exclusion Criteria: * Other diagnoses that involves bones or cartilage * Intraarticular steroid injections within 1 month of the trial investigation

Locations (1)

Pediatric research dept, Aarhus Universityhospital, Skejby

Aarhus, Region Midt, Denmark

Outcomes

Primary Outcomes

Joint cartilage thickness

Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist

Time frame: 1.5 years

Secondary Outcomes

Level of different biomarkers in serum and urine

Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD

Time frame: 1.5 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.