Orientation Agnosia: Clinical and Anatomical Study

University Hospital, Rouen34 enrolled

Overview

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Idem

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Cerebrovascular Disorders Brain Lesions

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 and 80 years * french language * right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion * informed consent Exclusion Criteria: * previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years * previous psychiatric history except depression without hospitalization \> one week or anxiety with maximum one anxiolytic treatment * drug or alcohol abuse * severe cranial traumatism * other severe chronic pathology * psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month * visual impairment * motor or sensory deficit sufficient to render impossible neuropsychological tests * patient without judicial or administrative liberty * measure of legal protection or no capable to express their consent * pregnancy or breastfeeding

Outcomes

Primary Outcomes

orientation agnosia evaluation

orientation agnosia test

Time frame: 1 week to 6 months (average)

Secondary Outcomes

associated clinical symptoms especially apraxia