Cardiovascular Events Based On Statin Initiation In The Elderly

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.31,603 enrolled

Overview

The purpose of this study is to compare rates and risk of primary cardiovascular events among elderly patients newly initiating therapy with atorvastatin or simvastatin. The specific objectives for this project are to: 1) examine the demographic and clinical characteristics of the elderly patients in whom atorvastatin or simvastatin was newly initiated; and 2) compare cardiovascular event rates in elderly patients in whom atorvastatin or simvastatin was newly initiated.

All subjects meeting sample definition, all inclusion criteria, and none of the exclusion criteria.

Study Type

OBSERVATIONAL

Enrollment

31,603

Conditions

Cardiovascular Dyslipidemia

Interventions

Atorvastatin InitiatorsOTHER

Retrospective database analysis no intervention performed.

Simvastatin InitiatorsOTHER

Retrospective database analysis no intervention performed.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥ 1 fill for atorvastatin or simvastatin (not including combination therapy) between 01 July 2006 and 30 November 2008 * Age ≥ 65 years as of the year of index date * Continuous enrollment with medical and pharmacy benefits during the analytic period Exclusion Criteria: * 1 or more fills for a statin or other dyslipidemia medication in the 12-month pre-index period * A pharmacy fill for clopidogrel or nitrates (except concomitant hydralazine) in the 12-month pre-index period * Patients with evidence of a cardiovascular event in the 12-month pre-index period. * Patients who received both atorvastatin and simvastatin on the index date * Patients with unknown gender or region * Patients who received dyslipidemia medications other than the index drug within 1 months (30 days) following the index date

Outcomes

Primary Outcomes

Number of Participants With Post-index Cardiovascular (CV) Events

CV events were defined as an inpatient or emergency department admission for heart failure (HF), myocardial infarction (MI), ischemic heart disease (IHD), cerebrovascular disease, peripheral vascular disease (PVD), aortic aneurysm, and/or revascularization. CV events were identified using medical claims.