Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

University of Sao Paulo30 enrolled

Overview

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Muscle Damage Inflammation

Interventions

BCAADIETARY_SUPPLEMENT

7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days

LeucineDIETARY_SUPPLEMENT

7 g of leucine + 7 g of alanine per day during 9 days

PlaceboDIETARY_SUPPLEMENT

14 g of alanine per day during 9 days

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Sedentary; * No muscle disorders; * Must be able to swallow tablets

Locations (1)

University of São Paulo - School of Physical Education and Sports

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Muscle maximal strength

Time frame: 4 days

Muscle edema

Time frame: 4 days

Muscle soreness

Time frame: 4 days

Secondary Outcomes

Muscle inflammation

Immunohistochemistry, protein expression.

Time frame: 4 days

Muscle damage

Serum creatine kinase

Time frame: 4 days

Data from ClinicalTrials.gov

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