Idarubicin Combined to Azacitidine in Int-2 or High Risk Myelodysplastic Syndromes

Inclusion Criteria: * Documented diagnosis of MDS, or CMML with WBC \< 13,000/mm3 that meets IPSS criteria for intermediate-2 or high-risk disease, * IPSS score ≥1.5 * Myocardial function do not contraindicate the use of idarubicin * Age ≥ 18 years * Performance Status ≤2 according to ECOG. * Serum creatinine \< 1.5 x ULN and normal levels of electrolytes (serum sodium 136-145 mmol/l, Potassium 3,5-4,5 mmol/l, alkaline Reserve 23-29 mmol/l, , Calcium 2,15-2,5 mmol/l, Phosphore 0,87-1,45 mmol/l) Serum aspartate aminotransferase (AST)/serum glutamic-oxaloacetic transaminase (SGOT) or alanine transaminase (ALT)/serum glutamate pyruvate transaminase (SGPT) \< 1.5 x upper limit of normal (ULN) * Serum total bilirubin \< 1.5 x ULN. * Must be able to adhere to the study visit schedule and other protocol requirements * Signed informed consent. Female subjects of childbearing potential must: • Accept effective contraception without interruption throughout the duration of study and up to three months after the end of treatment. Male subjects must * Agree to use condoms throughout study drug therapy, during any dose interruption and for one week after cessation of study therapy and up to three months after the final treatment if their partner is of childbearing potential and has no contraception. * Agree to learn the procedures for preservation of sperm Exclusion Criteria: * Uncontrolled infection * Prior therapy with anthracycline for MDS. * Eligible for an allogeneic stem cell transplantation. * Prior therapy with demethylating agents within the last 3 months * Prior therapy with Hematopoietic growth factor (ESA or G-CSF) agents or cytotoxic agents (oral chemotherapy, low doses AraC) within the last 30 days. * Prior history of malignancy other than MDS (except basal cell or squamous cell carcinoma or carcinoma in situ of the cervix or breast) * Pregnant or lactating females * Known HIV-1 positivity * Contra-indication to Anthracyclines