A Study of Complex Ventral Hernia Repair Utilizing the XenMatrix™ Surgical Graft With Component Separation

Inclusion Criteria: * Be able to undergo study procedures. * Have signed an Informed Consent form (ICF). * Be diagnosed with a ventral or incisional hernia that cannot be closed primarily in the opinion of the investigator. * Requires a component separation repair with the use of a biological graft. Exclusion Criteria: * Subject is participating in another device or drug study. * Subject has a life expectancy less than 4 years at the time of enrollment. * Any condition in the opinion of the investigator that would preclude the use of the XenMatrix™ Surgical Graft, or preclude the subject from completing the follow-up requirements. * Any subject with a defect the surgeon feels he/she cannot fully close. * Subjects with a BMI \> 50. * Subjects with connective tissue disorders. * Subjects with a history of cirrhosis. * Subjects with renal failure requiring dialysis. * Subjects on or suspected to be placed on chemotherapy or systemic immunosuppressive medications during any part of the study. * Transplant recipients. * Subjects taking corticosteroids for \>6 months (pre or post surgery). * Any bowel leak or infection that would preclude the use of the XenMatrix™ Surgical Graft in the opinion of the investigator. * The subject lives approximately 2 hours away from the study site and compliance with follow up requirements will be difficult in the opinion of the investigator.