Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Metastatic Colorectal Cancer

Inclusion Criteria: * Age of 18years or over * Patients who had failed more than 1 cycle of standard therapy with advanced or metastatic stage and with measurable lesions * Life expectancy \>/= 5 months * Not available to any of resectable surgery or radiotherapy * Patients with adequate organ(e.g. heart, kidney, liver)and bone marrow function, as defined by 1. Absolute neutrophil count \>/= 1.0 x 10\^9/L, Platelet count \>/= 75 x 10\^9/L 2. Total bilirubin \< 2.0 mg/dL 3. Aspartate Aminotransferase and/or Aspartate Aminotransferase \< 5 x Upper Limit Normal 4. creatinine \< 2 x Upper Limit Normal * ECOG status 0 to 2 * Female volunteers admitted to the study must be using a reliable means of contraception and must have a negative blood or urine pregnancy test at least 7days ago * Patients or their legal representatives who have signed the informed consent form. Exclusion Criteria: * Have inflammatory bowel diseases * Have severe diarrhea or ileus * Previous total colectomy * Have ileostomy * Known brain or spinal cord metastases * Patients who have received chemotherapy within the previous 4 weeks * Patients who have received radiotherapy related tp colorectal cancer within 4weeks * Patients who have participated in other clinical study within the previous 4weeks * Pregnancy or lactation period * Human Immunodeficiency Virus antibody (+) * Have active infection or serious concomitant systemic disorder incompatible with the study * Clinically hypertension or diabetes mellitus not well controlled with medication * Clinically significant cardiac disease(congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias) or myocardial infarction * Presence or history of malignancy other than colorectal cancer within 5years * Have severe Neurologic or psychological disorder * Patients who have history of allergy with this investigational drug(SB injection) * Obvious cognitive or physical impairment that would prevent participation