Natural History of Mineral Metabolism Parameters and Protein-bound Toxins in Incident Peritoneal Dialysis Patients

Universitaire Ziekenhuizen KU Leuven96 enrolled

Overview

The aims of this study are 1. To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules', and protein bound URM in incident peritoneal dialysis (PD) patients. 2. To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients. 3. To evaluate the natural history of biochemical parameters of mineral metabolism in incident PD patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Complication of Peritoneal Dialysis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Incident PD patients, defined as patients who started on PD as first renal replacement therapy less than 8 weeks before inclusion * written informed consent * age \> 18 years old

Locations (1)

University Hospital

Leuven, Vlaams-Brabant, Belgium

Outcomes

Primary Outcomes

natural history of clearances and serum parameters of mineral metabolism and protein-bound toxins

To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules, and protein bound URM in incident peritoneal dialysis (PD) patients.

Time frame: 15 years

Secondary Outcomes

determinants of generation rate of uremic retention solutes

To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients.

Time frame: 15 years on average