Neocytolysis in the Treatment of Renal Anemia With Erythropoieses Stimulating Agents (ESA)

Inclusion Criteria: * signed informed consent * age \> 18 years, dialysis dependent chronic renal failure * hemodialysis three times a week * Kt/V \> 1,2 od URR \> 65% * hemoglobin between 11 and 13 g/dl within the last 2 months * hemoglobin change +/- 1g/dl within the last 4 weeks * ESA for at least 8 weeks * Ferritin \> 300 ng/ml and Tsat \> 25% Exclusion Criteria: * Significant bleeding in the last 8 weeks * blood transfusion within the last 8 weeks * hemoglobin disorder * hemolysis * Malignant disease * Significant inflammation * Acute infection * CRP \> 30 mg/l * Temporary vascular dialysis access * Vitamin B12 deficiency * Folic acid deficiency * Not controlled hyperparathyroidism * Not controlled hypertension * Epilepsia within thze last 6 months * Thrombocyte count \> 500 x 10\^9 /l