Neuropsychiatric Effects of Deep Brain Stimulation in Patients With Parkinson's Disease

N/ACompletedNCT01306539

University of California, San Diego20 enrolled

Overview

Stimulation of the subthalamic nucleus will have effects on various aspects of neuropsychiatric function.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Parkinson's Disease

Interventions

Stimulation of the subthalamic nucleusPROCEDURE

Stimulation is delivered to the subthalamic nucleus at experimentally prescribed settings.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants diagnosed with idiopathic Parkinson's disease that meet criteria for treatment of their disease with STN-DBS. Participants will be selected for this study without regard for age (provided they are older than 18), gender or ethnic background. * Participants must have undergone subthalamic nucleus DBS surgery and be receiving treatment at the Scripps Clinic in La Jolla, CA Exclusion Criteria: * Patients under 18 years old. * Patients with mini-mental status scores below 26/30. * Patients with known psychiatric disease. * Patients who are too infirm, demented or dysarthric to clearly understand the consenting process, task instructions, or to communicate verbally regarding participation or non-participation.

Locations (1)

Scripps Clinic Torrey Pines

La Jolla, California, United States

Outcomes

Primary Outcomes

behavioral task performance

Participants will complete behavioral tasks at each of three visits to assess the effects of stimulation settings on task performance. At each research visit, behavior will be assessed beginning at 1 hour after the stimulation is adjusted to the experimental settings. Stimulation settings will be returned to each patient's treatment levels at the culmination of each visit.

Time frame: 1 to 2 hours

Data from ClinicalTrials.gov

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