High Dose and Low Dose of Atorvastatin in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)

Hormozgan University of Medical Sciences100 enrolled

Overview

The aim of this study is to compare the effect of high dose and low dose of Atorvastatin in reduction level of C-reactive protein (CRP) in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas.

This study compare the effect of 80mg atorvastatin followed by two 20mg daily atorvastatin with three 80mg daily atorvastatin in reduction of CRP in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas in 2009.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

100

Conditions

Cardiovascular Disease

Interventions

Low dose AtorvastatinDRUG

80mg atorvastatin followed by two 20mg daily atorvastatin

High dose atorvastatinDRUG

80mg daily atorvastatin for 72 hours

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with unstable angina with chest discomfort at rest with normal EKG or St depression (at least 0.1mv) in two consecutive leads or new and deep T inversion (at least 0.2mv) Exclusion Criteria: * Myocardial Infarction with ST elevation * Diabetes Mellitus * Previous statin use * Current infectious disease

Locations (1)

Hormozgan University of Medical Sciences

Bandar Abbas, Hormozgan, Iran

Outcomes

Primary Outcomes

CRP reduction

CRP reduction will be compared between two study groups

Time frame: 72 hours

Secondary Outcomes

Drug side effects

Headache, Myopathy

Time frame: 72 hours

Data from ClinicalTrials.gov

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