Comparing whether intravenous immune globulin or plasma exchange is superior in treating mechanically ventilated children with Guillain Barre syndrome.
Children with Guillain Barre syndrome (GBS) admitted to PICU at Mansoura University Children Hospital, Mansoura, Egypt with the need for mechanical ventilation were prospectively enrolled in the study. Cases were diagnosed according to clinical criteria. The decisions to initiate, wean and terminate mechanical ventilation were made independently by the attending consultant in accordance with the unit guidelines. Outcome variables measured were duration of mechanical ventilation, length of PICU stay and ability to walk unaided 4 weeks after PICU discharge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
41
Intravenous Immune Globulin at a dose 0f 0.4 g/kg/day for 5 consecutive days
Five sessions of plasma exchange, single plasma volume each, for 5 consecutive days
Mansoura University Children Hospital
Al Mansurah, Dakahlia Governorate, Egypt
Duration of mechanical ventilation
How many days did the mechanical ventilation continue
Time frame: 21 days (average)
PICU stay
How many days did the child spend on PICU
Time frame: 28 days (average)
Ability to walk
Ability of the child to walk unaided at 4 weeks from PICU admission
Time frame: 4 weeks from PICU discharge
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