Clinical Evaluation of Daptomycin Bone Penetration

Inclusion criteria: * Patient under treatment with daptomycin for more than 3 days with dosage at 6 mg/kg * Patient undergoing imperative surgery with bone withdrawal * Signed, and dated informed consent as defined by the Institutional Review Board * Male and female patients older than 18 years of age * Patients with social insurance * Patient with information on previous mandatory medical examination Exclusion criteria : * Patient with no treatment by daptomycin or with a dosage \< 6mg/kg or with less than 3 doses of daptomycine * Patient with no need for surgery * Patient younger than 18 years of age * Pregnant and nursing women * Patient refusal for inclusion * Patients with deprived liberty * Inability to complete the informed consent process because of problems with mental capacity