The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
108
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy
PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P\<0.05)
Time frame: June,2013
Cs and Cd
Cs and Cd in limb RIPC group were significantly higher than those in the control group at 30 and 60 min after OLV (all P\<0.05)
Time frame: June,2013
IL-6 and TNF-α
The IL-6 levels in the limb RIPC group were lower than those in the control group at 30 min, 6, 12, 24 and 48 h after operation (all P\<0.05), and there was a significant difference in TNF-α level between the groups (P\<0.01).
Time frame: June,2013
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