Formulations of Liposomal Local Anesthetics

University of Campinas, Brazil40 enrolled

Overview

This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated ropivacaine formulation for dental anesthesia.

This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated 0, 5% ropivacaine for dental anesthesia after maxillary infiltration.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

TRIPLE

Enrollment

Conditions

Underdosing of Local Anesthetics, Initial Encounter

Interventions

RopivacaineDRUG

1,8 mL of the local anesthetic formulations were injected at the apex of the maxillary right canine.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 44 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Exclusion Criteria: * Volunteers were free from cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and haematological diseases, psychiatric disorders and allergy to local anesthetics

Locations (1)

Piracicaba Dental School

Piracicaba, São Paulo, Brazil

Outcomes

Primary Outcomes

After anesthetic injection the pulpal response was assessed by an electrical pulp tester.

Time frame: 100 minutes

Secondary Outcomes

Duration of soft tissue anesthesia was measured as the time from beginning to end of lip and gingival numbness.

Time frame: 240 minutes

Data from ClinicalTrials.gov

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