Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Norwegian University of Science and Technology60 enrolled

Overview

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Myocardial Injury

Interventions

Exercise trainingBEHAVIORAL

exercise training

remote ischemic preconditioningPROCEDURE

remote ischemic preconditioning

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing coronary heart surgery and heart transplantation Exclusion Criteria: * myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin \> 140)

Locations (1)

Norwegian University of Science and Technology, Medical Faculty

Trondheim, Sør-Trondelag, Norway

Outcomes

Primary Outcomes

Mitochondrial respiration

Oxygraph (Strathkelvin)

Time frame: 1 hour

Data from ClinicalTrials.gov

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