Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia

Yonsei University42 enrolled

Overview

Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Thyroid Neoplasm

Interventions

fentanyl citrateDRUG

According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.

salineDRUG

According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 59 Years

Medical Language ↔ Plain English

Inclusion Criteria: * the patients undergoing general anaesthesia for elective thyroidectomy due to thyroid neoplasm. * ASA I-II. * 20-59 years old. * female only. Exclusion Criteria: * signs of difficult intubation. * risks for perioperative pulmonary aspiration. * history of chronic respiratory disease. * recent upper respiratory track infection. * previous and recent smoking history

Locations (1)

Severance Hospital

Seoul, South Korea

Data from ClinicalTrials.gov

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