ABSORB PHYSIOLOGY Clinical Investigation

Inclusion Criteria: 1. Participant must be a male of at least 18 years of age or a female that is post-menopausal and not on hormone replacement therapy. 2. Participant is able to verbally confirm understanding of risks, benefits and treatment alternatives and he/she or his/her legally authorized representative must provide written informed consent prior to any clinical investigation related procedure, as approved by the appropriate Ethics Committee of the respective clinical site. 3. Participant must have evidence of myocardial ischemia (e.g., stable or unstable angina, silent ischemia with a positive functional study). 4. Participant must be an acceptable candidate for coronary artery bypass graft (CABG) surgery. 5. Participant must agree to undergo all clinical investigation plan-required follow-up visits. 6. Participant must agree not to participate in any other clinical investigation for a period of 2 years following the index procedure. This includes clinical trials of medications and invasive procedures. Only questionnaire-based studies are allowed. Angiographic Inclusion Criteria: 1. A single de novo native coronary artery lesion suitable to be treated by either a BVS or a mDES. 2. Target lesion must be located in a native coronary artery in which the mean proximal and distal vessel diameter of the target lesion (Dmean) fall within the range of ≥ 2.25 mm and ≤ 3.25 mm and the target lesion length measures ≤ 22 mm as assessed by IVUS. 3. Target lesion must be located in the main branch of a major epicardial vessel (i.e., LAD, LCX, or RCA) with a visually estimated diameter stenosis of ≥ 50% and \< 100% with a TIMI flow of ≥ 1. 4. Participant must have an additional angiographically smooth (\< 40% diameter stenosis) non-target vessel to act as an intra-participant control vessel (self-control vessel). The self-control vessel must be the main branch of a major epicardial vessel (i.e., LAD, LCX, or RCA). 5. Coronary anatomy must be suitable for IVUS, OCT, and pressure and flow wire instrumentation. General Exclusion Criteria: 1. Participant has a known diagnosis of spontaneous acute myocardial infarction (AMI) within 14 days preceding the index procedure. 2. Participant has high-risk acute coronary syndrome (e.g., dynamic ST-T wave change on ECG or recurrent chest pain/nitrate-unresponsive prolonged chest pain at rest within 48 hours prior to the index procedure). 3. Participant has any evidence of myocardial infarct in the territory subtended by the proposed target vessel or self-control vessel. 4. Participant has current unstable arrhythmias. 5. Participant has chronic atrial fibrillation. 6. Participant has a known left ventricular ejection fraction (LVEF) \< 40%. 7. Participant has received a heart transplant or any other organ transplant or is on a waiting list for any organ transplant. 8. Participant has previously had CABG or mitral or aortic valve repair/replacement. 9. Participant is receiving or scheduled to receive chemotherapy for malignancy within 30 days prior to or after the index procedure. 10. Participant is receiving immunosuppressant therapy or has known immunosuppressive or autoimmune disease (e.g., human immunodeficiency virus, systemic lupus erythematosus, etc.). 11. Participant has a chronic systemic condition or medication likely to interfere with coronary physiology and/or conduit artery function (e.g., chronic inflammatory condition, chronic renal failure, or chronic obstructive pulmonary disease). 12. Participant has known renal insufficiency. 13. Participant is receiving or scheduled to receive any planned radiotherapy. 14. Participant is receiving chronic anticoagulation therapy (e.g., heparin, coumadin) at the onset of the clinical investigation. 15. Participant has a known hypersensitivity or contraindication to aspirin, heparin/bivalirudin, anti-platelet medications specified for use in the study (clopidogrel, prasugrel and ticlopidine, inclusive), everolimus, poly (L-lactide), poly (DL-lactide), cobalt, chromium, nickel, platinum, tungsten, acrylic and fluoro polymers, or contrast sensitivity that cannot be adequately pre-medicated. 16. Elective surgery is planned within the first 6 months after the index procedure that will require discontinuing aspirin, clopidogrel, prasugrel, or ticlopidine. 17. Participant has a platelet count \< 100,000 cells/mm3 or \> 700,000 cells/mm3, a WBC of \< 3,000 cells/mm3, or documented or suspected liver disease (including laboratory evidence of hepatitis) within 7 days prior to the index procedure. 18. Participant has a history of bleeding diathesis or coagulopathy or will refuse blood transfusions. 19. Participant has had a cerebrovascular accident/stroke (CVA) or transient ischemic neurological attack (TIA) within the past 6 months. 20. Participant has had a significant gastro-intestinal or significant urinary bleed within the past 6 months. 21. Participant has extensive peripheral vascular disease that precludes safe 6 French sheath insertion. 22. Participant has a history of paradoxical exercise-induced vasoconstriction that is consistent with myocardial bridging in the coronary anatomy. 23. Participant has other medical illness (e.g., cancer or congestive heart failure) or known history of substance abuse (alcohol, cocaine, heroin etc.) that in the judgment of the Investigator may cause non-compliance with the clinical investigation plan, confound the data interpretation or is associated with a limited life expectancy. 24. Participant is currently participating in another clinical investigation that has not yet reached its primary endpoint. 25. Percutaneous interventions for lesions in the third major epicardial vessel (the one that does not contain the target or the self-control vessel) were performed within 30 days preceding the index procedure or are planned to be done within 6 months following the index procedure. 26. Planned PCI procedures in the target vessel (and/or any of its side branches) or the self-control vessel (and/or any of its side branches) within 2 years following the index procedure. 27. Participant who does not suspend drugs that will influence vaso-function. Angiographic Exclusion Criteria 1. Target lesion meets any of the following criteria: 1. Left main location; 2. RCA aorto-ostial location (within 10 mm from expected proximal stent/scaffold edge); 3. LAD or LCX ostial location (within 10 mm from expected proximal stent/scaffold edge); 4. Involves a bifurcation with a side branch ≥ 2 mm in diameter, an ostial lesion \> 40% stenosed by visual estimation, or a side branch requiring pre-dilatation; 5. Total occlusion (TIMI flow 0) prior to wire crossing; 6. Excessive tortuosity proximal to or within the lesion; 7. Extreme angulation (≥ 90°) proximal to or within the lesion; 8. Heavy calcification in the lesion; 9. Located in a side branch. 2. Participant has a high probability that a procedure other than pre-dilatation, scaffold/stent implantation, and post-dilatation (if applicable) will be required at the time of index procedure for treatment of the target vessel (e.g., atherectomy, cutting balloon or brachytherapy). 3. The target vessel (and/or any of its side branches) or the self-control vessel (and/or any of its side branches) contains visible thrombus. 4. The target vessel or the self-control vessel has previously been treated by any PCI procedures. 5. A side branch of the target vessel or a side branch of the self-control vessel has received any percutaneous interventions within 30 days prior to the index procedure. 6. Another clinically significant lesion is located in the target vessel (and/or any of its side branches) or the self-control vessel (and/or any of its side branches) that may require PCI treatments within 2 years following the index procedure. 7. Participant has evidence of myocardial bridging in the coronary anatomy during the angiographic evaluation.