The purpose of this study is to investigate the efficacy and safety of autologous transplantation of adipose tissue derived mesenchymal stem cells (MSCs) in patient with progressive hemifacial atrophy.
Adipose derived mesenchymal stem cells (AdMSCs) represent an attractive and ethical cell source for stem cell therapy. With the recent demonstration of MSC homing properties, intramuscular aplications of MSCs to cell-damaged diseases have increased. In a human clinical trial, five patients who had suffered a progressive hemifacial atrophy( Romberg's disease) were intramuscular administered autologous hAdMSCs (1×10e7 cells/500ul) with autologous microlipoinjection one time.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
5
Intramuscular infusion of Autologous Adipose Tissue derived MSCs with autologous microlipoinjection. Dose: 1x10e7 cells/500ul/lipoinjection 20ml
ASAN Medical Center
Seoul, South Korea
The volume change of fatty layer
To evaluate the volume change of fatty layer using 3D camera.
Time frame: 24 weeks
Clinical lab tests
To assess the expression change of growth factors after tissue biopsy.
Time frame: 24 weeks
Fat absorption rate
To estimate the fat absorption rate using 3D computerized tomography and 3D camera.
Time frame: 24 weeks
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