Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy Subjects

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures * Males or females (of non-child bearing potential) aged 18 to 55 years (inclusive) * Minimum weight of 50 kg and a body mass index (BMI) of 18 to 35 kg/m2 (inclusive) * Males must be willing to use barrier contraception ie, condoms, from the first administration until 2 weeks after the last administration of the investigational product Exclusion Criteria: * History or presence of gastrointestinal, hepatic or renal disease (except for cholecystectomy) * Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of the investigational product * Subjects who smoke more than 5 cigarettes or the equivalent in tobacco per day * Absolute neutrophil count of less than 2500/mm3 or 2.5 x 109/L * Any previous treatment with fostamatinib or pioglitazone