Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction

Zealand University Hospital100 enrolled

Overview

The global epidemic of obesity in childhood continues to evolve and threaten future health and life expectancy primarily due to the increased incidence of cardiovascular disease. Obesity is strongly related to high blood pressure (hypertension) and both conditions pose a risk for target organ damage, which can follow a subject from childhood into adult life. The AORTA study will investigate central hemodynamics and organ damage in 100 obese children and adolescents in order to gain insight to the complex interplay of hypertension, obesity and subclinical damage in order to intensify more precise prevention, thereby reducing the future development of cardiovascular disease.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Central Blood Pressure Obesity Subclinical Organ Damage Children

Interventions

Lifestyle interventionBEHAVIORAL

Treatment protocol. The Children's Obesity Clinic Department of Paediatrics Holbaek Hospital, University of Copenhagen Denmark

Eligibility

Sex: ALLMin age: 10 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 10-18 * BMI for age and sex above 95 percentile * referred for treatment at the The Children's Obesity Clinic, Department of Paediatrics, Holbaek Hospital, University of Copenhagen * oral and written consent by their parents Exclusion Criteria: * children who can not cooperate to DEXA scanning or other procedures * linguistic difficulties that impair communication

Locations (2)

Division of Cardiology, Department of Medicine, Holbaek Hospital, University of Copenhagen

Holbæk, Denmark

RECRUITING

The Children's Obesity Clinic, Department of Paediatrics, Holbaek Hospital, University of Copenhagen

Holbæk, Denmark

RECRUITING