The purpose of this study is to investigate which changes in immunological biomarkers under treatment with fingolimod in patients with relapsing-remitting multiple sclerosis can be detected.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
447
Change from baseline of Cluster of Differentiation (CD)4+ naive T cells (C-C Chemokine Receptor Type 7+(CCR7+CD45RA+)
Time frame: 6 Months
Change from baseline of CD8+ naïve T cells (CCR7+CD45RA+)
Time frame: 6 months
Change from baseline of CD4+ central memory T cells (CCR7+CD45RA-)
Time frame: 6 months
Change from baseline of CD8+ central memory T cells (CCR7+CD45RA-)
Time frame: 6 months
Change from baseline of CD8+ effector memory T-cells (CCR7-CD45RA-)
Time frame: 6 months
Change from baseline of B-lymphocytes
Time frame: 6 months
Change from baseline of monocytes
Time frame: 6 months
Change from baseline of Natural Killer cells
Time frame: 6 months
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Novartis Investigative Site
Ostfildern, Baden-Wurttemberg, Germany
Novartis Investigative Site
Altenholz-Stift, Germany, Germany
Novartis Investigative Site
Andernach, Germany, Germany
Novartis Investigative Site
Celle, Germany, Germany
Novartis Investigative Site
Dortmund, Germany, Germany
Novartis Investigative Site
Göttingen, Germany, Germany
Novartis Investigative Site
Kastellaun, Germany, Germany
Novartis Investigative Site
Kiel, Germany, Germany
Novartis Investigative Site
Krefeld, Germany, Germany
Novartis Investigative Site
Leipzig, Germany, Germany
...and 51 more locations