Once-daily Therapy for Streptococcal Pharyngitis

Azad University of Medical Sciences

Overview

In some studies once daily amoxicillin therapy might be treatment of choice for Group A β-hemolytic Streptococcus pharyngitis in comparison with three to four times daily treatment with oral penicillin V.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Streptococcal Sore Throat

Interventions

AmoxicillinDRUG

Intramuscular Benzathin Penicillin GDRUG

It is mentioned underlined in page 10 in research. (Once the throat swab was taken and cultured on plate at the place where the child was examined, hygiene teacher was trained about how to prepare the oral amoxicillin suspension and how to give it to the child. 750 milligrams of amoxicillin was thereafter given to the patient and in order not to infect other school children, the patient was sent home. The following morning, the patient would come to school and was given the second dose of amoxicillin by the hygiene teacher. All oral drugs were bought from a creditable company. In the injection group, 600000 units of penicillin was administered to children who weigh less than 27 kilograms and 1200000 units of penicillin was administered to children who weigh more. After 48 hours, patients were examined again when the result of first culture was ready)

Eligibility

Sex: ALLMin age: 6 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: Inclusion Criteria: 1. Age of 6 to 15 years old. 2. The criteria in clinical examination including objective signs (fever, Erythema or exudate of tonsils, enlarged lymph nodes) and subjective sign(sore throat). Neck tenderness, abdominal pain and pharynx petechia were also considered. 3. No antibiotic was used during the week before. 4. -Performing throat culture before the initiation of drug administration 5. Positive throat culture indication GABHS 6. No previous history of allergy to penicillin . Exclusion Criteria: 1. Age of below 6 years old or above 15 years old. 2. No signs of pharyngitis in the clinical examination 3. Antibiotic use during the week before. 4. Throat culture was not performed before the initiation of drug administration. 5. Negative throat culture or the culture indicates a microorganism other than GABHS. 6. History of allergy to penicillin 7. Not using drugs or not following the treatment in the field of having the second culture performed.

Locations (1)

Islamic Azad University

Mashhad, Khorasan, Iran

Data from ClinicalTrials.gov

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