Patients undergoing cardiac surgery frequently develop neurologic complications, ranging from subtle cognitive changes to evident confusion, delirium, and stroke. This continuum of complications is commonly caused by embolization in the brain due to manipulation of atherosclerotic parts of the aorta ascendens (AA) during surgery. Timely detection of AA atherosclerosis before surgery enables the surgeon to consider changes of the surgical plan, to reduce the risk of embolization and thus subsequent neurologic complications. Various methods exist to visualize the AA to detect atherosclerosis. Epiaortic ultrasound scanning has become the gold standard, but is seldom used as it interferes often with surgical plan and can only be used after sternotomy. Transesophageal echocardiography (TEE) is a widely used imaging method permitting evaluation of the aorta preoperatively, but assessment of distal AA is hampered by interposition of air-filled trachea between esophagus and AA. The A-View® (Aortic-view) method, a modification of conventional TEE using a fluidfilled balloon, overcomes this limitation. The safety and diagnostic accuracy of the A-View® have successfully been shown in previous studies. The hypothesis of this study is that the use of A-View will reduce cerebral embolization secondary to a change of surgical technique.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
32
Pre-operative imaging of the thoracic aorta with A-View technique
New diffusion-weighted lesions on cerebral MRI
Time frame: 3 - 4 Days after intervention
The number, size, and location of new ischemic lesions on the postoperative DW-MRI
Time frame: 3 - 4 Days after intervention
Any neurologic event during the first six postoperative weeks, which is manifested as either stroke, or transient ischemic attack (TIA), epileptic insults, or delirium, or cognitive deficit
Time frame: 6 weeks postoperative
Stroke or TIA during the first three postoperative months
Time frame: 3 months postoperative
Delirium during hospital stay
Time frame: Until hospital discharge
Quality of life
Time frame: 6 weeks and 1 year after the intervention
Number of "HITS" detected by Transcranial Doppler
Time frame: peroperive
Incidence of Near Infrared Spectrography desaturations (NIRO 2000)
Time frame: Peroperative
Short psychometric test
Time frame: 6 weeks after intervention
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