The purpose of this study is to assess the indirect effects of a pneumococcal conjugate vaccine administered to infants on vaccinees' elder non-vaccinated siblings aged 3 to 7 years.
The purpose of this study is to assess the indirect effects of a pneumococcal conjugate vaccine administered to infants on vaccinees' elder non-vaccinated siblings aged 3 to 7 years. This study includes a cross-sectional sampling of nasopharyngeal and oropharyngeal swabs in 2011 and a register-based follow-up study for invasive disease, hospital-diagnosed pneumonia, tympanostomy tube surgery and outpatient antimicrobial treatment.
Study Type
OBSERVATIONAL
Enrollment
2,341
2 to 4 doses administered to the siblings in the cluster-randomized Finnish Invasive pneumococcal Disease Trial (ClinicalTrials.gov Identifier:NCT00861380)
2 to 4 doses administered to the siblings in the cluster-randomized Finnish Invasive pneumococcal Disease Trial (ClinicalTrials.gov Identifier:NCT00861380)
National Institute for Health and Welfare
Tampere, Finland
Carriage Due to Any Pneumococcal Serotype Included in the Ten-valent Pneumococcal Conjugate Vaccine (PCV10) Vaccine in Older Siblings of Children Vaccinated With Infant Schedules
Carriage due to any pneumococcal serotype included in the ten-valent pneumococcal conjugate vaccine (PCV10) vaccine in older siblings of children vaccinated with infant schedules. Nasopharyngeal swabs taken once at 3 to 7 years of age when the vaccinated sibling is at least 12 months of age
Time frame: one sampling at 3 to 7 years of age
Carriage Due to Any Pneumococcal Serotype
Nasopharyngeal and oropharyngeal swabs taken once at 3 to 7 years of age when the vaccinated sibling is at least 12 months of age
Time frame: one sampling at 3 to 7 years of age
Carriage Due to Haemophilus Influenzae
Nasopharyngeal and oropharyngeal swabs taken once at 3 to 7 years of age when the vaccinated sibling is at least 12 months of age
Time frame: one sampling at 3 to 7 years of age
Invasive Pneumococcal Disease
Register follow-up up to 8 years after the vaccination of the younger sibling in the family
Time frame: Up to 8 years
Hospital-diagnosed Pneumonia
Register follow-up up to 8 years after the vaccination of the younger sibling in the family
Time frame: Up to 8 years
Tympanostomy Tube Surgery
Register follow-up up to 8 years after the vaccination of the younger sibling in the family
Time frame: Up to 8 years
Outpatient Antibiotic Treatment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Register follow-up up to 8 years after the vaccination of the younger sibling in the family
Time frame: Up to 8 years