Accumulation of salt and water in patients with liver disease (so called liver cirrhosis) is possibly related to the increased effect of steroid hormones on salt reabsorption in the kidney. By reducing overall steroid production with the dexamethasone the accumulation of salt and water could be prevented.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
2
Daily administration of 2 mg of dexamethasone for 4 days
Daily administration of 2 mg of placebo for 4 days
University Hospital Inselspital
Bern, Canton of Bern, Switzerland
University Hospital Geneva
Geneva, Canton of Geneva, Switzerland
University Hospital Lausanne
Lausanne, Canton of Vaud, Switzerland
Daily sodium excretion of sodium in the urine
Time frame: 4 days
Daily potassium excretion
Time frame: 4 days
weight reduction
Time frame: 4 days
Reduction of doses of diuretics
Time frame: 4 days
Reduction of ascites
Time frame: 4 days
Reduction of cortisol excretion in the urine
Time frame: 4 days
Reduction of cortisol levels in the urine
Time frame: 4 days
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