The aim of this multicentric double blind study (randomized study) is to demonstrate the relationship between the amount of rTMS and the efficacy in the treatment of upper extremity motor deficits of stroke patients.
Repetitive transcranial magnetic stimulation (rTMS) can modulate excitability of the brain via non-invasive methods. In that sense, rTMS has been used to treat a variety of symptoms of stroke during last two decades. Especially, improvement of upper extremity function has been proved by many studies. However, it remains uncertain about the optimum amount of rTMS. The aim of this multicentric double blind study (randomized study) is to demonstrate the relationship between the amount of rTMS and the efficacy in the treatment of upper extremity motor deficits of stroke patients. Fifty-seven patients will be included with written consent. After randomization, the subject will receive 3 different amount of treatment rTMS-rTMS, Sham-rTMS, Sham-Sham) in double blind methods.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
2
1 Hz frequency, 15 minutes, intensity of 90% resting motor threshold, with one session a day, * Real: unaffected M1 hotspot * Sham: coil perpendicular to scalp
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Change in the Fugl-Meyer Assessment scale (upper extremity)
Time frame: Baseline, weekly during treatment, at 4-week follow-up,and at 12-week follow-up
Change in grip strength, lateral pinch force, tip pinch force, Purdue pegboard test, K-MBI, mRS,and brunnström stage
Time frame: Baseline, weekly during treatment, at 4-week follow-up,and at 12-week follow-up
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