Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery

Seoul National University Hospital60 enrolled

Overview

This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Cyanosis

Interventions

RIPC (remote ischemic preconditioning)OTHER

RIPC will be performed by four 5-min cycles of lower limb ischemia and 5 in reperfusion using blood-pressure cuff inflated to a pressure 15 mmHg greater than the systolic arterial pressure measured via arterial line.

Eligibility

Sex: ALLMin age: 1 MonthMax age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * open heart surgery under cardiopulmonary bypass: ventricular septal defect, tetralogy of Fallot Exclusion Criteria: * chromosomal defect * airway and parenchymal lung disease blood disorder * isolated atrail septal defect * immunodeficiency

Locations (2)

Seoul National University Hospital

Seoul, Seoul, South Korea

Seoul national university hospital

Seoul, South Korea

Outcomes

Primary Outcomes

troponin level

troponin level will be checked 1, 6, 12 and 24 hours after operation. Ater making a graph (troponin-time), area under the curve will bw calculated.

Time frame: within the 1 day after operation

Data from ClinicalTrials.gov

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